Associate Director/Director, Medical Chemistry

JOB SUMMARY

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

KEY RESPONSIBILITIES

• Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates
• Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
• Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
• Act as liaison between Iambic, CROs, and other external partners
• Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
• Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
• Communicate project updates clearly and effectively to the broader team and key stakeholders
• Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork

QUALIFICATIONS

• Ph.D. in Organic Chemistry and 8+ years of experience in Pharma/bio-tech drug discovery or Master's in Organic Chemistry and 12+ years of similar experience
• Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
• Ability to integrate multiple R&D disciplines into a successful strategic project plan
• Experience in leading projects and driving programs through the preclinical development process
• Experience working with computational chemists as part of project team in design of drug targets is required
• Strong interpersonal, communication, time management, and leadership skills
• Experience mentoring or leading junior chemists
• Creative problem solving and management of relationships with several stakeholders within and beyond the company

ABOUT IAMBIC THERAPEUTICS

Founded in 2019 and headquartered in San Diego, California, Iambic Therapeutics is disrupting the therapeutics landscape with its unique AI-driven drug-discovery platform. Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters with strong track records of success in delivering clinically validated therapeutics. The Iambic platform has been demonstrated to deliver high-quality, differentiated therapeutics to clinical stage with unprecedented speed and across multiple target classes and mechanisms of action. The Iambic team is advancing an internal pipeline of clinical assets to address urgent unmet patient needs. Learn more about the Iambic team, platform, and pipeline at iambic.ai.

MISSION & CORE VALUES

The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

ALSO

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.