Senior Scientist I, Drug Discovery Analytical Chemistry

The Position:

We are seeking an experienced, energetic, and enthusiastic individual to join the Analytical and Formulation Sciences group within the Drug Discovery department at Maze Therapeutics. This lab-based role is perfect for someone eager to deepen their expertise in analytical, formulation, and separation sciences along with physical chemical property measurement.

In this role, you will play a crucial part in supporting the Drug Discovery group as we strive to bring new medicines to patients. As a key member of project teams, you'll collaborate with experts in medicinal chemistry, DMPK, pharmacology, and biomarker departments. Together, you'll help advance our programs from initial screening to clinical nomination. You'll have the opportunity to work with top-of-the-line analytical instrumentation, including LCMSMS, Agilent HPLC 1260, Waters LCMS, PLM, Dissolution Apparatus, and a Rigaku Miniflex XRPD.

Your Impact:

• Independently develop chromatography methods with different modes such as normal phase, reverse phase, chiral and achiral for diverse compounds to support Drug Discovery projects.
• Apply extensive hands-on experience to operate, maintain and troubleshoot mass spectrometers such as single-Q, Triple-Q, Q-TOF, Orbitrap, as well as SFC chromatography instruments.
• Independently develop LCMS methods for characterizing advanced lead compounds, including but not limited to impurity profile, degradant identification, and structure elucidation of major impurities and degradants.
• Conduct solid form measurements including thermodynamic solubility, particle size, polyforms, melting point, salt, and water content analysis.
• Perform solid form measurements for advanced lead compounds; including solubility, particle size and polyform assessment, melting point, salt and water content of each lot.
• Author analytical protocols and reports. Provide suggestions and troubleshoot potential issues in ongoing drug discovery projects. Coordinate and provide oversight during assay transfer between Maze Therapeutics and external partner groups.
• You will provide scientific mentorship and technical guidance for junior colleagues.

Skills and Qualifications:

• PhD with 7+ years or Master's with 15+ years of relevant experience in an academic, biotech, or pharmaceutical industry
• Degree in Analytical Chemistry, Organic Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline
• Extensive hands-on experience with HPLC, LCMS, LCMSMS, ELSD, or CAD, Karl Fisher, Ion Chromatography, DSC, and reverse phase/normal phase/chiral chromatography
• Strong method development skills including experience with reverse phase, normal phase and SFC liquid chromatography, mass spectrometry, fragmentation mass spectrometry, ELSD/CAD, and SFC separations.
• Experience in analytical assay development, quantitative analysis, impurity elucidation, high throughput QC, and library screening.
• Excellent interpersonal and leadership skills for cross-functional collaboration.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company's pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together - Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission.

Impact Obsessed - We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True - Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $157,000 - $192,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.