Research Associate - Chemical Development

About the Department

The Boulder Site is home to the specialized technical operations/CMC team for oligonucleotides and RNAi therapeutics, continuing its legacy as the hub for all manufacturing-related activities for GalXC and GalXC-Plus investigational therapeutics developed from Novo Nordisk's acquisition of Dicerna Pharmaceuticals, Inc. in December 2021. With a new laboratory completed in 2021 to support analytical and process development, the CMC team works alongside Quality, Regulatory, Technical Operations and RNAi Early Development professionals at our Boulder, Colorado facility and works closely with our teams in Lexington, Massachusetts. Ranked the No. 1 Place to Live for the second consecutive year by U.S. News & World Report, Boulder is experiencing a renaissance in biotech investment and is one of the world's leading centers for oligonucleotide innovation and manufacturing. Together, we are driving change. Are you ready to make a difference?

The Position

Novo Nordisk Global Nucleic Acid Therapies (GNAT) is seeking highly motivated scientists to join its CMC Chemical Development team in Boulder, Colorado. The candidate will be expected to be a key technical resource developing innovative solutions for scalable syntheses, work-up, purifications, and isolations of oligonucleotides, establishing improvements in purity, yield, reproducibility, throughput and environmental impact. The successful candidate will ideally have a strong organic chemistry understanding with exposure to principles of process development, optimization, scale up and tech transfer into a manufacturing setting. This position will support therapeutic programs in multiple disease areas and will contribute to the development of scalable processes supporting Novo Nordisk oligonucleotide programs. Qualified candidates will be expected to work well in a collaborative team environment and be able to independently execute research across a wide range of oligonucleotide and organic chemistry projects.

Relationships

Reports to a more senior position within the Chemical development department. Manages mutually beneficial relationships within entire Technical Operations group. This may include external partners relevant to the planning and implementation of bulk manufacturing of oligonucleotide API. Provides excellent customer service and builds strong working relationships within Chemical Development and internal/external partners.

Essential Functions

Provide research and development support of ongoing chemical development projects utilizing state of the art techniques for preparation and analysis of oligonucleotides

Conduct laboratory work in safe, clean, efficient manner that ensures a clean, safe and organized working environment

Characterize starting materials, intermediates, and synthesized molecules using common analytical techniques such as HPLC and UV-Vis

Collaborate within the Technical Operations team to develop and optimize current manufacturing processes for key oligonucleotides and ensuring robustness in the developed processes

Document and summarize results in laboratory notebook, and written reports, drawing valid conclusions from concrete and abstract variables

Contribute to the team's knowledge through scientific literature review and discussions

Maintain and troubleshoot common laboratory equipment

Support authoring of research reports to be provided to internal and external manufacturing teams

Complete assignments that meet clearly defined deadlines and time schedules

Physical Requirements

0-10% overnight travel required. Ability to lift 0-10 lbs.

Qualifications

BA/BS or master's degree in chemistry, Biology or related field with 0 years of industrial experience, or a High School Diploma with 8+ years relevant lab experience

Ability to follow technical instructions with some independence

Demonstratable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization, and purification

Solid understanding of synthetic organic chemistry and/or oligonucleotide relevant reactions and mechanisms

Strong attention to detail and accuracy

Excellent time management and organizational skills

Self-motivated, enthusiastic & eager to learn with a proactive mindset

The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

This position is part of a job family. Title and level within the job family are evaluated based on a number of factors, such as years of experience, scope of work, proficiency, and business need. Candidates will be assessed for the most appropriate title and level within the job family during the recruitment process. The base range of pay for each title in this job family are as follows:

• RESEARCH ASSOCIATE - CHEMICAL DEVELOPMENT - $71,000 to $81,000
• SENIOR RESEARCH ASSOCIATE - CHEMICAL DEVELOPMENT - $81,000 to $87,000

In addition, this position is eligible for a company bonus based on individual and company performance. Novo Nordisk offers long-term incentive compensation and or company vehicles depending on the position's level or other company factors.

Employees are also eligible to participate in Company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flex-able vacation policy, and parental leave policy.

The job posting is anticipated to close on December 16, 2024 . The Company may however extend this time-period, in which case the posting will remain available on our careers website at

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we're life changing.

Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.